Sunday, 24 March 2013

Rebels enter C. African Republic capital

FILE - In this Jan. 5, 2013 file photo, government security forces in a pickup truck drive past a demonstration calling for peace as negotiators prepare for talks with rebels from the north, in downtown Bangui, Central African Republic Saturday. On Friday, March 22, rebels took the town of Damara, beginning a new march to take the capital, Bangui, said a rebel spokesman. Panic spread throughout the capital, with the neighborhoods closest to the northern gate of the city emptying out, as frightened residents locked up their shops, packed their bags and yanked their children out of school. Banks and government offices closed early.(AP Photo/Ben Curtis, File)

FILE - In this Jan. 5, 2013 file photo, government security forces in a pickup truck drive past a demonstration calling for peace as negotiators prepare for talks with rebels from the north, in downtown Bangui, Central African Republic Saturday. On Friday, March 22, rebels took the town of Damara, beginning a new march to take the capital, Bangui, said a rebel spokesman. Panic spread throughout the capital, with the neighborhoods closest to the northern gate of the city emptying out, as frightened residents locked up their shops, packed their bags and yanked their children out of school. Banks and government offices closed early.(AP Photo/Ben Curtis, File)

FILE - In this Jan. 2, 2013 file photo, a convoy of Chadian soldiers fighting in support of Central African Republic president Francois Bozize moves along the road in Damara, about 70km (44 miles) north of the capital Bangui, Central African Republic Wednesday, Jan. 2, 2013. On Friday, March 22, rebels took the town of Damara, beginning a new march to take the capital, Bangui, said a rebel spokesman. Panic spread throughout the capital, with the neighborhoods closest to the northern gate of the city emptying out, as frightened residents locked up their shops, packed their bags and yanked their children out of school. Banks and government offices closed early.(AP Photo/Ben Curtis, File)

FILE - In this Jan. 8, 2013 photo, Francois Bozize, president of the Central African Republic, speaks to the media in front of a map of the country in the colors of its flag, at the presidential palace in Bangui, Central African Republic. On Friday, March 22, rebels took the town of Damara, beginning a new march to take the capital, Bangui, said a rebel spokesman. In power since 2003, Bozize is himself the result of a rebel occupation. After years as a high-ranking military officer, Bozize launched a rebellion in 2001, taking Bangui two years later, when the then-president was out of the country.(AP Photo/Ben Curtis, File)

FILE - In this Jan. 2, 2013 file photo, a Chadian soldier fighting in support of Central African Republic president Francois Bozize sits on a truck in a convoy of other Chadian soldiers near Damara, about 70km (44 miles) north of the capital Bangui, Central African Republic. On Friday, March 22, rebels took the town of Damara, beginning a new march to take the capital, Bangui, said a rebel spokesman. Panic spread throughout the capital, with the neighborhoods closest to the northern gate of the city emptying out, as frightened residents locked up their shops, packed their bags and yanked their children out of school. Banks and government offices closed early.(AP Photo/Ben Curtis, File)

BANGUI, Central African Republic (AP) ? Hundreds of rebels penetrated the capital of Central African Republic on Saturday, posing the gravest threat to President Francois Bozize's government in a decade. In at least one part of the city, the insurgents faced resistance and were battling their way through, a group monitoring the situation said.

The capital of this desperately poor nation was plunged into darkness after fighters cut power to much of the city. State radio went dead, and fearful residents cowered in their homes Saturday night.

The rebels, who signed a peace agreement in January that was to allow Bozize to stay in power until 2016, have been threatening to overthrow the president unless he meets their demands.

The rebels come from several different armed groups that have long challenged the government and have an array of grievances and demands. They are now accusing Bozize of failing to abide by the terms of the latest deal signed two months ago, with the help of mediators from neighboring countries.

"For us, there is no other solution than the departure of Francois Bozize," Eric Massi, a rebel spokesman, said from Paris by telephone late Saturday.

Massi confirmed that the rebel forces had entered Bangui and were continuing their advance into the capital in an effort to secure the city.

Rebel fighters had rapidly seized a dozen towns in December and January but never entered the capital before agreeing to the negotiations that led to the failed January peace accord.

Guy Moussa, who lives in the PK12 neighborhood on the north side of the city, told The Associated Press that hundreds of rebels were seen entering the city around 6 p.m.

Coverseas Worldwide Assistance, a Swiss-based crisis management firm with contacts on the ground, said that rebels, known as Seleka, had split into three columns. One had set up a base in PK12, while a second headed further into Bangui and met no resistance. A third column entered Bangui from the west, where the rebels faced resistance and combat was ongoing.

Earlier in the afternoon, non-essential United Nations personnel taking a bus to the airport had been stopped by a group of angry youths.

"No one leaves this country. You will stay here. If we die, we all die together," the youths shouted, according to U.N. employee Debonheur Deotar.

The growing unrest is the latest threat to the stability of Central African Republic, a nation of 4.5 million that has long been wracked by rebellions and power grabs. The president himself took power in 2003 following a rebellion, and his tenure has been marked by conflict with myriad armed groups.

Bozize's whereabouts late Saturday were not immediately known. On Friday, state radio announced that he had returned from South Africa where he was meeting with that country's president, Jacob Zuma.

Massi, the rebel spokesman, said Bozize was believed to be sheltering at the South African Embassy in Bangui.

South Africa has sent troops and equipment to support Central African Republic forces. The rebels insist the foreign troops leave, and, as part of their demands, they want their own fighters integrated into the national army.

On Friday, the rebels seized Damara, which had been the boundary line drawn up by regional forces before the January peace accord was signed. The move marked a serious escalation by the rebels, who went on to take the town of Bossembele early Saturday, said military spokesman Lt. Evrard Tekremoyen.

The insurgents then drove to the neighboring town of Boali and took control of three power plants that serve the town and the capital, residents said.

The rebels also cut off the electrical grid, plunging some of Bangui into darkness, Elisabeth Kofio, the director of Central African Republic Energy, said on the radio.

Earlier in the week, Bozize had offered to release some political prisoners, but the rebels said the gestures were too little, too late.

___

Larson reported from Dakar, Senegal. Associated Press writer Rukmini Callimachi also contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-03-23-Central%20African%20Republic-Rebel%20Advance/id-1cd772095ba544149f0d2a56f8ab043e

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Saturday, 23 March 2013

Weekend in politics: Obama wraps up Middle East trip, and more

By Steve Keating ORLANDO, Florida (Reuters) - Rory McIlroy's decision to skip the Arnold Palmer Invitational surprised the tournament host, who expressed his disappointment on Wednesday that the world number one was not at Bay Hill this week. The 83-year-old Palmer said he had jokingly suggested he might break McIlroy's arm if he did not show up but did not try to force the young Northern Irishman into making an appearance. "Frankly, I thought he was going to play, and I was as surprised as a lot of people when he decided he was not going to play," said Palmer. ...

Source: http://news.yahoo.com/blogs/ticket/weekend-politics-obama-wraps-middle-east-trip-more-100353494--politics.html

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Immune-cell therapy could strengthen promising melanoma treatment

Mar. 21, 2013 ? A new study of genetically modified immune cells by scientists from UCLA and the California Institute of Technology could help improve a promising treatment for melanoma, an often fatal form of skin cancer.

The research, which appears March 21 in the advance online edition of the journal Cancer Discovery, was led by James Heath, a member of UCLA's Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research and UCLA's Jonsson Comprehensive Cancer Center. Heath is a professor of molecular and medical pharmacology at UCLA and also holds the Elizabeth W. Gilloon Chair in Chemistry at Caltech.

The melanoma treatment uses T cells -- immune cells that play a major role in fighting infection -- taken from patients with melanoma. The cells are then genetically modified in the laboratory so that when they are reintroduced into a patient's bloodstream, they specifically attack melanoma tumors. In early clinical trials, this treatment was shown to shrink tumors dramatically in many patients, but the positive effects were often short-lived.

The UCLA and Caltech researchers found that after the engineered T cells were returned to patients, their efficacy faded within two to three weeks. Surprisingly, however, once the engineered cells were no longer effective, a new group of non-engineered T cells arose that had a similar tumor-killing effect that lasted even longer, the scientists discovered.

Using newly developed nanotechnology chips to perform multidimensional and multiplexed immune-monitoring assays, the researchers were able to examine at high resolution single engineered T cells taken at different times from patients undergoing the therapy, each of whom had a different level of response to the treatment.

"The engineered T cells did not recover their tumor-killing effect," Heath said, "but after one month, another group of T cells appeared that did have tumor-killing effects for another 90 days. Those were not the genetically engineered T cells, and they appeared to be a byproduct of a process called 'antigen spreading' by the original engineered cells. After 90 days, those cells lost their tumor-killing ability as well."

Antigen spreading is a process by which a T cell that has been engineered to attack a particular tumor expands its immune response to other T cells in the body, which then attack the same tumor but are focused on different antigens. (Antigens are substances that trigger a response by the body's immune system.) Scientists may be able to use this process, Heath stressed, to improve T cell-based treatments for melanoma.

"Our results have led us to possible ways to improve the T cell therapy to extend its positive effect," Heath said. "We need to incorporate strategies that maintain the functional properties of the engineered T cells used for therapy. This might include modifying how we grow the T cells in the laboratory to make their tumor-killing effect last longer or make them resistant to the effects of the patient's T cells as they recover from pretreatment chemotherapy conditioning and possibly increase the antigen spreading of anti-tumor T cells."

UCLA professor of medicine Dr. Antoni Ribas was one of Heath's key collaborators on the research.

"One of the possible approaches to resolve the problem identified by this study is to use engineered blood stem cells -- instead of the peripheral blood used in the original trials -- with this therapy in the hope that the engineered blood stem cells will provide a renewable source of engineered T cells," said Ribas, a member of UCLA's Broad Stem Cell Research Center and Jonsson Cancer Center.

Caltech's Chao Ma, the study's first author, said the findings and the use of the new nanotechnology assay process hold promise for treatments of other disease as well.

"This study points to the value of these single-cell functional analyses for probing the successes and failures of a sophisticated immunotherapy," he said. "I am excited to see its use as a monitoring tool to understand a spectrum of other cellular immunotherapies in the near future."

This research was funded by the National Cancer Institute, the Jean Perkins Foundation, The California Institute for Regenerative Medicine, UCLA's Broad Stem Cell Research Center, the Seaver Institute, the PhaseOne Foundation, the Garcia-Corsini Family Fund, the Caltech/UCLA Joint Center for Translational Medicine, the Melanoma Research Alliance, a Rosen Fellowship and UCLA's Jonsson Comprehensive Cancer Center.

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Story Source:

The above story is reprinted from materials provided by University of California - Los Angeles. The original article was written by Shaun Mason.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. C. Ma, A. F. Cheung, T. Chodon, R. C. Koya, Z. Wu, C. Ng, E. Avramis, A. J. Cochran, O. N. Witte, D. Baltimore, B. Chmielowski, J. S. Economou, B. Comin-Anduix, A. Ribas, J. R. Heath. Multifunctional T-cell Analyses to Study Response and Progression in Adoptive Cell Transfer Immunotherapy. Cancer Discovery, 2013; DOI: 10.1158/2159-8290.CD-12-0383

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/Pnu-6HA8OmE/130322104324.htm

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Bloomberg: ?We're Going To Have More Visibility And Less Privacy,' Drones And Surveillance Coming

mq-9_reaper_-_090609-f-0000m-7771“We’re going to have more visibility and less privacy. I don’t see how you stop that,” admitted New York City Mayor Michael Bloomberg in a surprisingly candid interview about the future of the surveillance state in the Big Apple. While admitting that increased surveillance was “scary” and that governments will have to be thoughtful with their laws, he seemed to side with prioritizing radical transparency, especially through the use of automated drones, “but what?s the difference whether the drone is up in the air or on the building? I mean intellectually I have trouble making a distinction.” This puts Bloomberg squarely at odds with the growing number of states and congress members either enacting or proposing moratoriums on the use of drones. Indeed, he went on to imply that the fears against drones were somewhat unjustified, especially since security cameras already exist: “The argument against using automation, it’s this craziness– oh, it’s Big Brother. Get used to it. When there’s a murder, a shooting, a robbery of something the first thing the police do is go to every single building in the neighborhood and say let’s see your security camera.” The NY Daily news notes that the New York Civil Liberties union has identified roughly 2,4000 cameras already affixed on Manhattan buildings–a presence that is likely to increase if Bloomberg’s most recent interview is to be believed. Lest Bloomberg be labeled as a surveillience hawk, the interview took on a tone of inevitability, rather than advocacy: “Everybody wants their privacy, but I don’t know how you’re going to maintain it.” Listen to part of the interview with WOR-AM host John Gambling, below. We’ll have more analysis soon.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/uV8cZfaFdTU/

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Now Play Us Takes the Hassle Out of Organizing Group Gaming Sessions

Now Play Us Takes the Hassle Out of Organizing Group Gaming Sessions Dozens of matchmaking services have come and gone, and most of them kind of suck. Now Play Us is a new contender that wants to simplify the process of finding people to play your favorite games with, whether you know them or not, and whether you want to play right now or later.

Now Play Us actually uses Twitter as its backbone. You sign up with Twitter, and once you've created an account you can connect your Xbox Live, Steam, PS3, Battle.net, or other account to the service. From there, click the events tab to see all of the scheduled gaming sessions available to join, their time/date, and the platform of choice. Click any one of them to join the player list, leave a comment, or tweet the event so more people will come play too.

You can just as easily create your own events on Now Play Us: just click the calendar icon in the toolbar to schedule a gaming session and put it on the calendar. You can even get notifications when other players join your game. It's easy, fast, and you can even add all events to your personal calendar. The service is brand new, so don't expect a ton of games to join just yet, but there's a good selection of events, and once you add your games and invite your friends, everyone benefits. Besides, it's better than just joining random pubs, right?

Now Play Us

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/aBKfD-28iaI/now-play-us-takes-the-hassle-out-of-organizing-group-gaming-sessions

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Oracle shares dive after severe third-quarter miss; analysts cut views

SAN FRANCISCO (Reuters) - Oracle Corp's shares sank more than 8 percent on Thursday a day after the company reported sharply disappointing third-quarter new software revenue, which it blamed on poor sales execution

The severe miss, reported after the market close on Wednesday, triggered a series of price-target cuts from Wall Street.

The stock was on track for its largest single-day loss since December 2011, when it also reported disappointing quarterly results. The shares were down 8.2 percent at $32.83 at midday.

Credit Agricole reduced its rating on Oracle, the world's No. 3 software maker, to "underperform" from "outperform" and cut its share target price to $35 from $38. Evercore Partners cut its rating to "equal-weight" from "overweight."

Other brokerages, including Wedbush, Stifel and RBC, reduced their price targets but maintained their recommendations.

The company, which is battling fast-growing rivals like Salesforce and Workday in the field of Internet-based software services, on Wednesday reported a 2 percent slip in new software sales and Internet-based subscriptions. Analysts had on average projected a gain of 8 percent.

The company forecast that new software license sales, a key indicator of future revenue, will rise 1 percent to 11 percent this quarter. It warned that revenue from its ailing hardware business will continue to shrink significantly.

(Editing by Leslie Adler)

Source: http://news.yahoo.com/oracle-shares-dive-severe-third-quarter-miss-analysts-161748967--sector.html

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Friday, 22 March 2013

What Improvements Make Your Home Best? - Costa Mesa Real Estate

Spring, has almost sprung, and that?s when our Costa Mesa real estate market usually gets moving. ?I say usually because inventory levels barely have a hearbeat(!) and are lower than they have ever been. ?But back to the matter at hand- how do you get the most money for your home when you go to sell it.

There are lots of things that I can do to a Costa Mesa real estate home that will spruce it up for market, but it?s the upgrades and remodeling that really add money to the bottom line.

What adds the most? ?At the right is an infographic that spells out what gives you the most bang for your buck on home improvement projects. ?Mind you, this is a California wide sample. ?What works in Sacramento doesn?t always work in Costa Mesa, but generally the trends are the same. ?Following national trends on HGTV is ok, but every market is local.

The List

What are the top requests in Costa Mesa real estate from actual buyers? In order, here?s the most important?improvements?to make:

1. Updated/Remodeled Kitchen

2.?Open Living Space

3. Remodeled Bathrooms

4. Vinyl Windows

5. Large Master Bedroom/Master Suite

Those are the recurring top 5. ?Those come up over and over in Costa Mesa real estate when I am working with buyers. ?Generally, if you are going to sell, and there are major/pricey improvements you have not made, it can be wise to attend to those things prior to sale. ?Do you badly need a new roof? ?New paint? New carpet? ?Do the tings that are easy to tackle so it doesn?t seem like your home needs lots and lots of improvments. ?Buyers seldomly want to replace a roof or put new windows in. ?They do it because they have to, not because they really want to.

Need help or ideas with your home improvements? ?I often consult with people prior to their making updates on what would be smart. ?I?m always?available, feel free to call or connect with me. ?Colin Delaney 714-743-9882 or?E-mail me.

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Source: http://costamesarealestate.com/what-improvements-make-your-home-best/

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